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Publications 2017-07-10T15:45:58+00:00

PUBLICATIONS

2016

Massagué, J., Obenauf, AC. (2016). Metastatic colonization by circulating tumour cells. Nature. 529(7586):298-306 (abstract(download)

Mlecnik, B., Bindea, G., Angell, HK., Maby, P., Angelova, M., Tougeron, D., Church, SE., Lafontaine, L., Fischer, M., Fredriksen, T., Sasso, M., Bilocq, AM., Kirilovsky, A., Obenauf, AC., Hamieh, M., Berger, A., Bruneval, P., Tuech, JJ., Sabourin, JC., Le Pessot, F., Mauillon, J., Rafii, A., Laurent-Puig, P., Speicher, MR., Trajanoski, Z., Michel, P., Sesboüe, R., Frebourg, T., Pagès, F., Valge-Archer, V., Latouche, JB., Galon, J. (2016). Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability. Immunity. 44(3):698-711 (abstract(download)

Mlecnik, B., Bindea, G., Kirilovsky, A., Angell, HK., Obenauf, AC., Tosolini, M., Church, SE., Maby, P., Vasaturo, A., Angelova, M., Fredriksen, T., Mauger, S., Waldner, M., Berger, A., Speicher, MR., Pagès, F., Valge-Archer, V., Galon, J. (2016). The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis. Sci Transl Med. 8(327):327ra26 (abstract(download)

2015

Jacob, LS., Vanharanta, S., Obenauf, AC., Pirun, M., Viale, A., Socci, ND., Massagué, J. (2015). Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations. Cancer Res. 75(18):3713-9 (abstract(download)

Obenauf, AC., Massagué, J. (2015). Surviving at a distance: organ specific metastasis. Trends Cancer. 1(1):76-91 (abstract(download)

Obenauf, AC., Zou, Y., Ji, AL., Vanharanta, S., Shu, W., Shi, H., Kong, X., Bosenberg, MC., Wiesner, T., Rosen, N., Lo, RS., Massagué, J. (2015). Therapy-induced tumour secretomes promote resistance and tumour progression. Nature. 520(7547):368-72 (abstract(download)

Wiesner, T., Lee, W., Obenauf, AC., Ran, L., Murali, R., Zhang, QF., Wong, EW., Hu, W., Scott, SN., Shah, RH., Landa, I., Button, J., Lailler, N., Sboner, A., Gao, D., Murphy, DA., Cao, Z., Shukla, S., Hollmann, TJ., Wang, L., Borsu, L., Merghoub, T., Schwartz, GK., Postow, MA., Ariyan, CE., Fagin, JA., Zheng, D., Ladanyi, M., Busam, KJ., Berger, MF., Chen, Y., Chi, P. (2015). Alternative transcription initiation leads to expression of a novel ALK isoform in cancer. Nature. 526(7573):453-7 (abstract(download)

2014

Mlecnik, B., Bindea, G., Angell, HK., Sasso, MS., Obenauf, AC., Fredriksen, T., Lafontaine, L., Bilocq, AM., Kirilovsky, A., Tosolini, M., Waldner, M., Berger, A., Fridman, WH., Rafii, A., Valge-Archer, V., Pagès, F., Speicher, MR., Galon, J. (2014). Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients. Sci Transl Med. 6(228):228ra37 (abstract(download)

Valiente, M., Obenauf, AC., Jin, X., Chen, Q., Zhang, XH., Lee, DJ., Chaft, JE., Kris, MG., Huse, JT., Brogi, E., Massagué, J. (2014). Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell. 156(5):1002-16 (abstract(download)

2013

Bindea, G., Mlecnik, B., Tosolini, M., Kirilovsky, A., Waldner, M., Obenauf, AC., Angell, H., Fredriksen, T., Lafontaine, L., Berger, A., Bruneval, P., Fridman, WH., Becker, C., Pagès, F., Speicher, MR., Trajanoski, Z., Galon, J. (2013). Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 39(4):782-95 (abstract(download)

2012

Katz, SF., Lechel, A., Obenauf, AC., Begus-Nahrmann, Y., Kraus, JM., Hoffmann, EM., Duda, J., Eshraghi, P., Hartmann, D., Liss, B., Schirmacher, P., Kestler, HA., Speicher, MR., Rudolph, KL. (2012). Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. Gastroenterology. 142(5):1229-1239.e3 (abstract(download)

Mathiesen, RR., Fjelldal, R., Liestøl, K., Due, EU., Geigl, JB., Riethdorf, S., Borgen, E., Rye, IH., Schneider, IJ., Obenauf, AC., Mauermann, O., Nilsen, G., Christian Lingjaerde, O., Børresen-Dale, AL., Pantel, K., Speicher, MR., Naume, B., Baumbusch, LO. (2012). High-resolution analyses of copy number changes in disseminated tumor cells of patients with breast cancer. Int J Cancer. 131(4):E405-15 (abstract(download)

2011

Wiesner, T., Obenauf, AC., Murali, R., Fried, I., Griewank, KG., Ulz, P., Windpassinger, C., Wackernagel, W., Loy, S., Wolf, I., Viale, A., Lash, AE., Pirun, M., Socci, ND., Rütten, A., Palmedo, G., Abramson, D., Offit, K., Ott, A., Becker, JC., Cerroni, L., Kutzner, H., Bastian, BC., Speicher, MR. (2011). Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet. 43(10):1018-21 (abstract(download)

2010

Obenauf, AC., Schwarzbraun, T., Auer, M., Hoffmann, EM., Waldispuehl-Geigl, J., Ulz, P., Günther, B., Duba, HC., Speicher, MR., Geigl, JB. (2010). Mapping of balanced chromosome translocation breakpoints to the basepair level from microdissected chromosomes. J Cell Mol Med. 14(8):2078-84 (abstract(download)

Roetzer, KM., Schwarzbraun, T., Obenauf, AC., Hauser, E., Speicher, MR. (2010). Further evidence for the pathogenicity of 15q24 microduplications distal to the minimal critical regions. Am J Med Genet A. 152A(12):3173-8 (abstract)

Schallmoser, K., Bartmann, C., Rohde, E., Bork, S., Guelly, C., Obenauf, AC., Reinisch, A., Horn, P., Ho, AD., Strunk, D., Wagner, W. (2010). Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions. Haematologica. 95(6):867-74 (abstract)

Van Raamsdonk, CD., Griewank, KG., Crosby, MB., Garrido, MC., Vemula, S., Wiesner, T., Obenauf, AC., Wackernagel, W., Green, G., Bouvier, N., Sozen, MM., Baimukanova, G., Roy, R., Heguy, A., Dolgalev, I., Khanin, R., Busam, K., Speicher, MR., O’Brien, J., Bastian, BC. (2010). Mutations in GNA11 in uveal melanoma. N Engl J Med. 363(23):2191-9 (abstract(download)

Wiesner, T., Obenauf, AC., Cota, C., Fried, I., Speicher, MR., Cerroni, L. (2010). Alterations of the cell-cycle inhibitors p27(KIP1) and p16(INK4a) are frequent in blastic plasmacytoid dendritic cell neoplasms. J Invest Dermatol. 130(4):1152-7 (abstract(download)

2009

Begus-Nahrmann, Y., Lechel, A., Obenauf, AC., Nalapareddy, K., Peit, E., Hoffmann, E., Schlaudraff, F., Liss, B., Schirmacher, P., Kestler, H., Danenberg, E., Barker, N., Clevers, H., Speicher, MR., Rudolph, KL. (2009). p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet. 41(10):1138-43 (abstract)

Geigl, JB., Obenauf, AC., Waldispuehl-Geigl, J., Hoffmann, EM., Auer, M., Hörmann, M., Fischer, M., Trajanoski, Z., Schenk, MA., Baumbusch, LO., Speicher, MR. (2009). Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays. Nucleic Acids Res. 37(15):e105 (abstract)

Reinisch, A., Hofmann, NA., Obenauf, AC., Kashofer, K., Rohde, E., Schallmoser, K., Flicker, K., Lanzer, G., Linkesch, W., Speicher, MR., Strunk, D. (2009). Humanized large-scale expanded endothelial colony-forming cells function in vitro and in vivo. Blood. 113(26):6716-25 (abstract)

Schallmoser, K., Rohde, E., Bartmann, C., Obenauf, AC., Reinisch, A., Strunk, D. (2009). Platelet-derived growth factors for GMP-compliant propagation of mesenchymal stromal cells. Biomed Mater Eng. 19(4-5):271-6 (abstract)

Schwarzbraun, T., Obenauf, AC., Langmann, A., Gruber-Sedlmayr, U., Wagner, K., Speicher, MR., Kroisel, PM. (2009). Predictive diagnosis of the cancer prone Li-Fraumeni syndrome by accident: new challenges through whole genome array testing. J Med Genet. 46(5):341-4 (abstract)

Wiesner, T., Obenauf, AC., Geigl, JB., Vallant, EM., Speicher, MR., Fink-Puches, R., Kerl, H., Cerroni, L. (2009). 9p21 deletion in primary cutaneous large B-cell lymphoma, leg type, may escape detection by standard FISH assays. J Invest Dermatol. 129(1):238-40 (abstract)  (download)

2008

Geigl, JB., Obenauf, AC., Schwarzbraun, T., Speicher, MR. (2008). Defining ‘chromosomal instability’. Trends Genet. 24(2):64-9 (abstract(download)

Schallmoser, K., Rohde, E., Reinisch, A., Bartmann, C., Thaler, D., Drexler, C., Obenauf, AC., Lanzer, G., Linkesch, W., Strunk, D. (2008). Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum. Tissue Eng Part C Methods. 14(3):185-96 (abstract)